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3g, h). Ligelizumab binding forces the Cε3 domains right into a far more symmetrical arrangement that intently aligns With all the IgE dimer twofold axis defined with the Cε4 domains and that is incompatible with FcεRI binding. the flexibility of ligelizumab to bind and dissociate the IgE-Fc3-four:FcεRI complexes implies which the advanced can dynamically obtain conformational states during which the secondary Cε3 area isn't going to sterically block ligelizumab binding.
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